ABSTRACT
The intracellular accumulation of sorbitol, a product, which arises from polyol pathway: one of glucose metabolic pathways, has been said to be one of the pathogens for diabetic retinopathy. So, to obtain fundamental data regarding the time of administratin as well as the dosage of aldose reductase inhibitor(ARI) which inhibits the formation of sorbitol, we examined the interrelationship between RBC-sorbitol and glucose, HbAlc, and the association of RBC-Sorbitol with the severity of diabetic retinopathy in fifty NIDDM patients(20 No diabetic retinopathy, 10 mild NPDR, 10 sever NPDR, 10 PDR). In results, there was no association between RBC-sorbitol and glucose(r=0.172), between RBC-sorbitol and HbAlC(r=0.262), also there was no discernible RBC-Sorbitol level in each degree of diabetic retinopathic severity (F`=0.67, p>0.05), and wide variation of RBC-sorbitol level in each diabetic patients. Thus, for the progression of diabetic retinopathy, the duration time of high sorbitol level was predicted to be of more important value than the sorbitol level at the time of diagnosis. Therefore, we have shown through the research that ARI needs to be administered early on when RBC-Sorbitol level is higher than normal and in terms of ARI dosage, administering differenct ARI dosage according to different sorbitol level of each patient will be more effective for prevention and treatment of diabetic retinopathy.
Subject(s)
Humans , Aldehyde Reductase , Diabetes Mellitus, Type 2 , Diabetic Retinopathy , Diagnosis , Glucose , Metabolic Networks and Pathways , SorbitolABSTRACT
AIM:To investigate the effects of Zhouluotong (Radix Astragali, Ramulus Cinnamomi, Radix Angelicae Sinensis, Radix Rchmannia, Herba Asari, etc.) on nerve function and polyol pathway in streptozotocin diabetic rats. METHODS: Streptozotocin diabetic rats were administrated with Zhouluotong for 8 weeks. Effects of drugs on sciatic never morphological alterations, sciatic never conduction velocity, aldose reductase activity, Na +,K + ATPase activity and sciatic nerve polyol contents were determined. RESULTS: Compared with diabetic group, sciatic never morphological alterations was improved, sciatic never conduction velocity was increased, aldose reductase activity was depressed and Na +,K + ATPase activity was increased in each administrated group. Sorbitol and gloucose contents were decreased in Zhouluotong groups. CONCLUSION: Zhouluotong could improve metabolism and function of peripheral nerve issue in streptozotocin diabetic rats. As a result of that, it could prevent diabetic peripheral neuropathy in streptozotocin diabetic rats.
ABSTRACT
Diabetic microangiopathy is one of the most common chronic diabetic complications,which is associated with the genetic predispositions and environmental factors.Well-controlled blood glucose alone can not reduce the morbility or prevent the process of diabetic microangiopathy.The therapy aiming at the pathogenesis is an urgent request.The various proteins related to the development and progression of diabetic microangiopathiy were reviewed,aiming at providing the potential target for early diagnosis and efficient therapy.
ABSTRACT
The red blood cell sorbitol levels of 23 healthy subjects and 66 diabetic patients were measured enzymatically. Results showed that erythrocyte sorbitol levels of both IDDM (17) and NIDDM (38) patients with poor control were significantly higher than that of the controls and positively correlated with the coincident plasma glucose concentration, 24-hour urinary glucose excretion and HbA1c. There was no significant difference between the red cell sorbitol concentration of NIDDM with normal blood glucose level and that of the normal group; moreover, red cell sorbitol levels did not sig-nificantly correlated with FBG in both groups. Although there was no significant difference between the FBG of poorly controlled IDDM and NIDDM groups, red blood cell sorbitol levels were significantly different in both groups. This suggested that red blood cell sorbitol level could be used as an indicator of diabetic control.